High Grade Prostatic Intraepithelial Neoplasia
The simplest way to describe pin is as a precancerous condition but as is often the case in prostate disease the situation is actually much more complex. High grade prostatic intraepithelial neoplasia hgpin focal.
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High grade prostatic intraepithelial neoplasia on needle biopsy when your prostate was biopsied the samples taken were studied under the microscope by a specialized doctor with many years of training called a pathologist.
High grade prostatic intraepithelial neoplasia. Based on how abnormal the patterns of cells look they are classified as. 60 year old man with foamy gland high grade prostatic intraepithelial neoplasia am j surg pathol 2000 24 140 microscopic histologic description hallmark feature is acinar cells with presence of prominent nucleoli visible at a 20x magnification or lower. As high grade prostatic intraepithelial neoplasia is found in multiple cores close follow up is suggested with a re biopsy when indicated.
Prostatic intraepithelial neoplasia pin is defined as a neoplastic growth of epithelial cells within preexisting prostatic acini or ducts. In this condition there are changes in how the prostate gland cells look under the microscope but the abnormal cells don t look like they are growing into other parts of the prostate like cancer cells would. Hgpin shares many morphological genetic and molecular signatures with prostate cancer.
Often considered to be a precursor to adenocarcinoma of the prostate high grade prostatic intraepithelial neoplasia hgpin consists of benign prostatic ducts lined with atypical epithelial cells. The pathology report tells your treating doctor the diagnosis in each of the samples to help manage your care. Its predictive value for the development of.
What is prostatic intraepithelial neoplasia pin. It may be referred to simply as prostatic intraepithelial neoplasia pin. Turp prostate tissue transurethral resection of the prostate turp.
In any given year as many as 16 of men who undergo prostate biopsies will learn they have pin short for prostatic intraepithelial neoplasia. Acute and chronic inflammation. High grade prostatic intraepithelial neoplasia hgpin has been established as a precursor to prostatic adenocarcinoma.
High grade prostatic intraepithelial neoplasia hgpin is an abnormality of prostatic glands and believed to precede the development of prostate adenocarcinoma the most common form of prostate cancer. The incidence of hgpin on biopsy averages 5 2 with a range from 1 to 25 which is usually attributed to inter observer variability. Of the pins high grade pin high grade prostatic intraepithelial neoplasia hgpin grade 2 3 is considered to be a precursor for pca development.
Although not diagnostic of prostate cancer on a needle biopsy many morphologic molecular histopathological epidemiological and genetic studies have offered strong evidence that high grade prostatic intraepithelial neoplasia hgpin is in fact a precursor lesion to development of invasive prostatic adenocarcinoma.
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