Thick Ascending Loop Of Henle Function
The inner medullary collecting ducts however are permeable to urea. It is the primary site for sodium reabsorption.
Reabsorption And Secretion Along The Loop Of Henle Anatomy
Thick ascending limb is the upper part and it is lined by simple cuboidal epithelium.
Thick ascending loop of henle function. 2 the reabsorption of sodium chloride also produces concentration gradients that drive the countercurrent multiplier system in the medulla and medullary rays and thus concentrates the urine. The tal is impermeable to water. This transporter moves one sodium ion one potassium ion and two chloride ions across the apical membrane.
In addition henle s thick segment is a major location of magnesium and calcium ion resorption. In the cortical and outer medullary collecting ducts water is reabsorbed while urea remains increasing the osmolarity of the tubular fluid. The primary function of the loops of henle and the thick ascending limb of the distal tubule is the concentration of urine utilizing a principle called countercurrent multiplication the medulla possesses a gradient of urea and salt with increasing concentrations of these solutes closer to the papillae.
1 they reabsorb sodium chloride which dilutes the urine. Thin ascending limb is the lower part of the ascending loop of henle and it is lined by simple squamous epithelium. The thick ascending loop of henle is a major resorptive segment of the nephron and accounts for resorption of nearly a quarter of the filtered load of sodium chloride and potassium ions.
Other functions of the loop of henle include. This function allows production of urine that is far more concentrated than blood limiting the amount of water needed as intake for survival. The principal function of the loop of henle appears to be the recovery of water and sodium chloride from the urine.
Thick ascending limb is thicker than the thin ascending limb. Within the nephron of the kidney the ascending limb of the loop of henle is a segment of the heterogenous loop of henle downstream of the descending limb after the sharp bend of the loop this part of the renal tubule is divided into a thin and thick ascending limb. The primary site of sodium reabsorption in the loop of henle is the thick ascending limb tal.
Some sources simply refer to a thin limb. The thick descending limb is less important than the thin descending limb so often the terms descending limb and thin descending limb are used interchangeably. In this context the thin ascending limb of loop of henle would be included.
Thick ascending limbs of henle s loop have at least three major roles. In the tal sodium reabsorption is active via the nkcc2 transporter on the apical membrane. The ascending limb of the loop of henle distal and cortical collecting ducts are impermeable to urea.
The thick portion is also known as the distal straight tubule in contrast with the distal convoluted tubule downstream. The thick ascending limb expresses a sodium potassium chloride cotransporter and helps reabsorb approximately a third of the filtered sodium and chloride from the fluid in the tubular lumen into the blood. Homeostatic mechanisms to regulate the extracellular fluid volume.
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