Single Stranded Binding Protein
Replication recombination and repair. Recf pathway proteins facilitate the displacement of ssb from ssdna allowing the reca protein to form protein filaments on the ssdna region which facilitates the process of recombinational dna repair.
Single Stranded Dna Binding Protein And Exogenous Recbcd
Single stranded dna is produced during all aspects of dna metabolism.
Single stranded binding protein. Gene references into functions. Single strand dna binding protein ssb is a protein found in escherichia coli e. Dna that has been converted from a double stranded form to a single stranded form can be said to have been denatured.
Plays an important role in dna replication recombination and repair. Coli bacteria that binds to single stranded regions of deoxyribonucleic acid. Asymmetric unit biological assembly export animated image.
The regions of single stranded ss dna that result from dna damage are immediately coated by the ssdna binding protein ssb. The ssb protein is a class of dna binding proteins that holds the single stranded dna to facilitate dna replication. Six herpes virus group common genes encode proteins that likely constitute the replication fork machinery including a two subunit dna polymerase a helicase primase complex and a single stranded dna binding protein.
What is a single stranded binding protein ssb. Coli single stranded dna binding protein chymotryptic fragment complex with dna pdb code 1eyg show. Acts as a sliding platform that migrates on dna via reptation.
Single stranded dna binding protein ssb binds with high affinity in a cooperative manner to single stranded dna and does not bind well to double stranded dna. Binds to ssdna and to an array of partner proteins to recruit them to their sites of action during dna metabolism. Ssb or its 10 c terminal amino acids stimulates the atpase activity of radd pubmed 27519413.
The encoded protein may also play a role in telomere repair. After binding single stranded dna ssb destabilizes helical duplexes thereby allowing dna polymerases to access their substrate more easil. Single stranded dna binding protein 2 sequence specific single stranded dna binding protein 2.
In bacteria especially in the e coli the ssb protein found as a tetramer with four different domains or structures. A variant of this gene may be associated with survival in human glioblastoma patients. Single strand binding protein is attached to these post replication fork single strands of dna preventing their reannealing that is reforming the double stranded double helix state.
The human herpesvirus 1 hhv 1 single strand dna binding protein icp8 is a 128kda zinc metalloprotein. All the subunits are identical and having a molecular weight of 19kda. Provided by refseq sep 2016 other designations.
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