Non Nucleoside Reverse Transcriptase Inhibitors Nnrtis

Non nucleoside reverse transcriptase inhibitors nnrtis when hiv infects a cd4 cell in a person s body it copies its own genetic code into the cell s dna. Non nucleoside reverse transcriptase inhibitors nnrtis act in a similar fashion albeit in a slightly different location on the same enzyme.

National Guidelines For The Clinical Management Of Hiv Aids

This class of drugs was first described at the rega institute for medical research belgium.

Non nucleoside reverse transcriptase inhibitors nnrtis. Non nucleoside reverse transcriptase inhibitors nnrtis non nukes or non nucleosides treatment these drugs also prevent hiv from using reverse transcriptase to make copies of itself but in a different way. As their name implies they target the hiv viral reverse transcriptase slowing the integration of the hiv nucleic acid into the human dna strand. Hiv uses reverse transcriptase to convert its rna into dna reverse transcription.

Non nucleoside reverse transcriptase inhibitors nnrtis is a class of drugs for antiretroviral therapy art for human immunodeficiency virus hiv infection. An nnrti may be part of a cocktail of drugs that each target hiv at a different point in its replication cycle to help prevent hiv from causing aids acquired immunodeficiency syndrome. In this way the cell is then programmed to create new copies of hiv.

Blocking reverse transcriptase and reverse transcription prevents hiv from replicating. Non nucleoside reverse transcriptase inhibitors nnrtis bind to and block hiv reverse transcriptase an hiv enzyme. Drug class reverse transcriptase reverse transcription.

Non nucleoside reverse transcriptase inhibitors nnrtis are the third class of antiretroviral drugs that were developed. The introduction of two new non nucleoside reverse transcriptase inhibitors nnrtis in the past 5 years and the identification of novel nnrti associated mutations have made it necessary to reassess the extent of phenotypic nnrti cross resistance. Hiv s genetic material is in the form of rna.

In all cases patents remain in force until beyond 2007.

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